项目名称：应激下情绪与记忆的认知神经机制
项目负责人：罗跃嘉
资助类别：重点项目
起止年月：2016年01月 至 2020年12月
项目摘要：
1.中文摘要：
应激对人类的生理功能、心理与行为活动有极大调节作用，是当前多学科交叉的重大前沿科学问题，与促进国民的心理健康水平密切相关。本项目将通过整合最新脑功能成像、基因和认知实验技术，在神经回路、系统、全脑、直至行为等多个层面上，揭示人类情绪与记忆的个体易感性特征及其基因基础，进而检验在“杏仁核—腹内侧前额叶”与“海马—腹内侧前额叶”等关键神经环路上的可塑性，建立应激条件下情绪与记忆网络特征变化的全脑图谱，从而为提高个体应激应对能力、干预和治疗应激相关精神障碍和身心疾病提供重要的科学依据。本项目拟完成2项有国际显示度的标志性成果，发表20篇以上有国际影响力的高水平论文。项目申请人先后负责基金委“杰青”和重点项目，项目组成员在近5年发表SCI论文上百篇，其中包括若干篇顶尖学术期刊论文。项目依托单位与合作单位已装备必要的认知神经科学设备，将在学术、队伍和技术等方面提供有力保证。
关键词：情绪；记忆；应激；脑机制；脑成像
2.Abstract：
The adverse effects of stress on the brain and cognition have been recognized as one of the major risk factors of human health and disease. Understanding the neurocircuitry and its plastisticity of these effects has taken a great significance on the promotion of mental health. The overall goal of our proposed project is to identify core brain circuits, systems, and networks underlying adverse effects of stress on emotion and memory, as well as neurogenetics of individual differences in these effects and their plasticity. That is, to reveal the neural plasticity of the two key circuits: the" amygdala-ventromedial prefrontal (vmPFC) "circuit and the" hippocampus - vmPFC " circuit in anxiety and memory impairments under stress, and to establish the characteristic changes of the whole brain atlas in the emotional and memory brain network under stress. Outcomes of the proposed projects will provide crucial scientific basis to enhance individual's ability to deal with stress, intervention and treatment of stress-related mental disorders and health. The proposed research is expected to achieve at least 2 landmark achievements with international visibility, and publish more than 20 high-level papers in high-profile journals. The research team consists of by six outstanding young researchers. The principal investigator (PI) has been awarded the "Outstanding Youth" project and the National key project of the NSFC. The team members has published over one hundred journal articles (SCI) in recent 5 years, including high-profile journals like Science, Nature Neuroscience, PNAS, Biological Psychiatry and The Journal of Neuroscience. The collaboration platform equipped with large-scale neuroscienctific equipment will also provide a strong guarantee in terms of academic, team, technology and research platform.
Keywords: emotion; memory; stress; brain mechanism; neuroimaging
