项目名称：帕金森病合并轻度认知障碍不同亚型的脑影像和血液生化研究
项目负责人：张浩波博士
资助类别：国家自然科学基金青年项目
起止年月：2018年1月-2020年12月
1.中文摘要：
帕金森病伴轻度认知障碍(PD-MCI)是一种常见的PD类型，痴呆转化率高。然而关于PD-MCI生物学指标的研究数量有限，且研究结果不一致，这可能与多数研究没有细分PD-MCI的认知障碍亚型有关。本课题计划对PD患者进行全面认知功能检查，从中筛选出90名PD-MCI患者，并对其进行认知障碍亚型分类，然后与30名不伴MCI的PD患者和30名正常对照一起进行核磁扫描以得到灰白质结构和功能网络指标，并进行五种血液生化分子浓度检测；本课题还计划追踪一年半后被试在认知功能、脑影像和血液生化上的改变。本课题将通过组间比较，检查不同PD-MCI亚型在脑影像和生化指标上的病理特征；利用关联分析，探索PD-MCI患者的认知功能与脑影像和生化分子之间的相关性；通过纵向研究，调查不同PD-MCI亚型在认知功能、脑影像以及血液生化上的病理发展进程。研究成果将有助于PD-MCI的早期诊断和向痴呆转化的早期预警。
2.Abstract：
Mild cognitive impairment in Parkinson’s disease (PD-MCI) is a common type of PD, which has a far higher conversion rate to dementia than PD without MCI. However, the studies of neuroimaging and biochemistry markers on PD-MCI are still insufficient, and their results were inconsistent, which is possibly due to the lack of division of PD-MCI subtypes in these studies. This project plans to use a series of neuropsychological assessments to comprehensively evaluate the cognitive functions of early-stage PD patients, and from them to draw 90 PD-MCI patients, and then differentiate different PD-MCI subtypes. This project plans to conduct multi-modal MRI scanning on 90 PD-MCI patients, 30 PD patients without MCI, and 30 healthy elderly adults to acquire their grey matter and white matter structural metrics as well as functional network metrics. This project also plans to measure the levels of five biochemical molecules in the peripheral blood of all participants. This project will also track the changes of the participants in cognitive function, neuroimaging and biochemical biomarkers at a 1.5-year interval. The aim of this project is to examine the pathological characteristics of different PD-MCI subtypes in neuroimaging and biochemical biomarkers through group comparison; using correlation analysis to explore the correlations of cognitive function with neuroimaging and biochemical biomarkers in PD patients; and to investigate the specific pathological progressions of different PD-MCI subtypes in cognitive function, neuroimaging and biochemical biomarkers by the longitudinal study design. The findings could be beneficial for the early diagnosis of PD-MCI and the early warning for the conversion to PD dementia.
