项目名称：焦虑与执行功能的动态交互脑网络研究
项目负责人：罗跃嘉
亚类说明：重点国际(地区)合作研究项目
起止年月：2020年01月至 2024年12月
项目摘要
1.中文摘要：
焦虑是当今社会常见而重要的负性情绪，执行功能是认知加工的核心成分。过度的焦虑会损害认知功能和工作绩效，加大焦虑障碍等精神疾病的发病风险，妨碍社会和谐，增加社会成本。然而我们对“焦虑影响认知”过程中脑网络交互的深层神经机制的认识还十分有限，对支持和影响脑网络功能的神经振荡、分子、神经递质的因果调控机制的理解也很匮乏。本项目拟从行为到机制，从全脑网络到分子水平，通过整合fMRI和EEG等脑功能成像、神经生化测试和认知实验技术，揭示焦虑情绪对执行功能的影响及潜在的动态脑网络连接模式与神经振荡机制，并通过tDCS等神经调控技术揭示因果关系；使用药物干预和血液炎症因子测量，从神经递质和炎症因子的细胞和分子层面，深入挖掘网络动态交互的底层神经机制。预期通过系列研究，从基础理论层面，建立和验证“焦虑调节执行功能的动态脑网络模型”；从临床应用层面，寻找神经递质、炎症分子、脑网络水平的生物学标记物和干预靶点。
关键词：焦虑；情绪；执行功能；动态脑网络；脑功能成像
2.Abstract：
Anxiety, a common negative emotional state, and executive function, the core component of cognition, are intertwined neural processes in the brain. Excessive anxiety can impair cognitive function and task performance, increase the risk of mental illness such as anxiety disorder, impede social harmony and lead to extra social costs. However, our knowledge on how anxiety affects cognition is still limited in terms of functional network interactions in the brain, let alone more detailed information on dynamic neural oscillations and molecular mechanisms concerning inflammation and neurotransmitters. Capitalizing on advanced technologies integrating multimodel (behavioral tests, fMRI, EEG, TMS/tDCS) and mutidisciplinary (neuropsychology, neurobiochemistry, and biomedical enginerring) approaches for probing the brain, this project aims to (1) characterize dynamic network interactions underlying the impact of state (study I) and trait (study II) anxiety on executive functions; (2) explore inflammation effects on large-scale networks in patients with general anxiety disorder (stduy III); and (3) examine the modulation of network interactions identified in (1) by norepinephrine. Successful carrying out of this proposed project will on one hand establish and validate a dynamic network model for the impact of anxiety on executive functions; and on the other hand provide biological markers for improving precise and individualized diagnosis, intervention, and prognosis associated with anxiety.
Keywords: anxiety; emotion; executive functions; dynamic brain networks; functional neuroimaging
